Synthesis and in vitro antitumor activities of lupeol dicarboxylic acid monoester derivatives
Identifieur interne : 001159 ( Main/Exploration ); précédent : 001158; suivant : 001160Synthesis and in vitro antitumor activities of lupeol dicarboxylic acid monoester derivatives
Auteurs : Weijie Li [République populaire de Chine] ; Jing Hao [République populaire de Chine] ; Yeyu Xiao [République populaire de Chine]Source :
- Archives of Pharmacal Research [ 0253-6269 ] ; 2013-12-01.
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Abstract
Abstract: Ten lupeol dicarboxylic acid monoester derivatives as new potent antitumor agents were synthesized and evaluated for in vitro antitumor activities against A549, LAC, HepG2 and HeLa cell lines. Among them, compounds 1–5 showed excellent antitumor activities against all tested tumor cell lines and compounds 6–10 exhibited high activities against A549, HepG2 and HeLa cells, exceeded lupeol, lupanol and doxorubicin. Compound 2 displayed the highest potent antitumor activities with IC50 values of 5.78 μM against A549 cell, 2.38 μM against LAC cell, 6.14 μM against HepG2 cell and 0.00842 μM against HeLa cell.
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DOI: 10.1007/s12272-013-0155-x
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Pharm. Res.</title><idno type="ISSN">0253-6269</idno><idno type="eISSN">1976-3786</idno><imprint><publisher>Springer Netherlands</publisher><pubPlace>Dordrecht</pubPlace><date type="published" when="2013-12-01">2013-12-01</date><biblScope unit="volume">36</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1447">1447</biblScope><biblScope unit="page" to="1453">1453</biblScope></imprint><idno type="ISSN">0253-6269</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0253-6269</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antitumor activity</term><term>Lupeol derivative</term><term>Synthesis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Ten lupeol dicarboxylic acid monoester derivatives as new potent antitumor agents were synthesized and evaluated for in vitro antitumor activities against A549, LAC, HepG2 and HeLa cell lines. Among them, compounds 1–5 showed excellent antitumor activities against all tested tumor cell lines and compounds 6–10 exhibited high activities against A549, HepG2 and HeLa cells, exceeded lupeol, lupanol and doxorubicin. Compound 2 displayed the highest potent antitumor activities with IC50 values of 5.78 μM against A549 cell, 2.38 μM against LAC cell, 6.14 μM against HepG2 cell and 0.00842 μM against HeLa cell.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Li, Weijie" sort="Li, Weijie" uniqKey="Li W" first="Weijie" last="Li">Weijie Li</name></noRegion><name sortKey="Hao, Jing" sort="Hao, Jing" uniqKey="Hao J" first="Jing" last="Hao">Jing Hao</name><name sortKey="Li, Weijie" sort="Li, Weijie" uniqKey="Li W" first="Weijie" last="Li">Weijie Li</name><name sortKey="Xiao, Yeyu" sort="Xiao, Yeyu" uniqKey="Xiao Y" first="Yeyu" last="Xiao">Yeyu Xiao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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